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1

Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases

Daniel Riester, Christian Hildmann, Patricia Haus, Antonia Galetovic, Andreas Schober, Andreas Schwienhorst, Franz-Josef Meyer-Almes

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 723 KB

english, 2009

2

Novel fluorescence based receptor binding assay method for receptors lacking ligand conjugates with preserved affinity: Study on estrogen receptor α

Silke Christoph, Franz-Josef Meyer-Almes

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 178 KB

english, 2003

3

Histone deacetylase inhibitor assay based on fluorescence resonance energy transfer

Daniel Riester, Christian Hildmann, Andreas Schwienhorst, Franz-Josef Meyer-Almes

Journal:

Analytical Biochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 253 KB

english, 2007

4

Compact, cost-efficient microfluidics-based stopped-flow device

Regina Bleul, Marion Ritzi-Lehnert, Julian Höth, Nico Scharpfenecker, Ines Frese, Dominik Düchs, Sabine Brunklaus, Thomas E. Hansen-Hagge, Franz-Josef Meyer-Almes, Klaus S. Drese

Journal:

Analytical and Bioanalytical Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 713 KB

english, 2011

5

Inhibitor-mediated stabilization of the conformational structure of a histone deacetylase-like amidohydrolase

Stefanie Kern, Daniel Riester, Christian Hildmann, Andreas Schwienhorst, Franz-Josef Meyer-Almes

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 567 KB

english, 2007

6

Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases

Leonhard M. Henkes, Patricia Haus, Felix Jäger, Joachim Ludwig, Franz-Josef Meyer-Almes

Journal:

Bioorganic & Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 843 KB

english, 2012

7

Thailandepsins: Bacterial Products with Potent Histone Deacetylase Inhibitory Activities and Broad-Spectrum Antiproliferative Activities

Wang, Cheng, Henkes, Leonhard M., Doughty, Leah B., He, Min, Wang, Difei, Meyer-Almes, Franz-Josef, Cheng, Yi-Qiang

Journal:

Journal of Natural Products

Année:

2011

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2011

8

The Structure of the RNA Polymerase-Promoter Complex: DNA-bending-angle by Quantitative Electrooptics

Franz-Josef Meyer-Almes, Hermann Heumann, Dietmar Porschke

Journal:

Journal of Molecular Biology

Année:

1994

Fichier:

PDF, 398 KB

1994

9

The cyclic AMP receptor promoter DNA complex:A comparison of crystal and solution structure by quantitative molecular electrooptics

Franz-Josef Meyer-Almes, Dietmar Porschke

Journal:

Journal of Molecular Biology

Année:

1997

Langue:

english

Fichier:

PDF, 246 KB

english, 1997

10

Fluorescence cross-correlation: A new concept for polymerase chain reaction

Rudolf Rigler, Zeno Földes-Papp, Franz-Josef Meyer-Almes, Cyra Sammet, Martin Völcker, Andreas Schnetz

Journal:

Journal of Biotechnology

Année:

1998

Langue:

english

Fichier:

PDF, 473 KB

english, 1998

11

Mechanism of intercalation into the DNA double helix by ethidium

Meyer-Almes, Franz Josef, Porschke, Dietmar

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 1003 KB

english, 1993

12

Highly Ligand Efficient and Selective N -2-(Thioethyl)picolinamide Histone Deacetylase Inhibitors Inspired by the Natural Product Psammaplin A

Baud, Matthias G. J., Haus, Patricia, Leiser, Thomas, Meyer-Almes, Franz-Josef, Fuchter, Matthew J.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 964 KB

english, 2013

13

Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes

Meyners, Christian, Baud, Matthias G. J., Fuchter, Matthew J., Meyer-Almes, Franz-Josef

Journal:

Journal of Molecular Recognition

Année:

2014

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2014

14

Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors

Meyners, Christian, Baud, Matthias G.J., Fuchter, Matthew J., Meyer-Almes, Franz-Josef

Journal:

Analytical Biochemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2014

15

A fluorescence lifetime-based binding assay for acetylpolyamine amidohydrolases fromPseudomonas aeruginosausing a [1,3]dioxolo[4,5-f][1,3]benzodioxole (DBD) ligand probe

Meyners, Christian, Wawrzinek, Robert, Krämer, Andreas, Hinz, Steffen, Wessig, Pablo, Meyer-Almes, Franz-Josef

Journal:

Analytical and Bioanalytical Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 379 KB

english, 2014

16

Mechanism of Binding of the Inhibitor ( E )-3-(Furan-2-yl)- N -hydroxyacrylamide to a Histone Deacetylase-like Amidohydrolase

Sykora, Jaromir, Meyer-Almes, Franz-Josef

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 2.35 MB

english, 2010

17

Enzyme Inhibition Assays Using Fluorescence Correlation Spectroscopy: A New Algorithm for the Derivation of k cat / K M and K i Values at Substrate Concentrations Much Lower than the Michaelis Constant

Meyer-Almes, Franz-Josef, Auer, Manfred

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 78 KB

english, 2000

18

Azobenzene switch with a long-lived cis-state to photocontrol the enzyme activity of a histone deacetylase-like amidohydrolase

Korbus, Michael, Balasubramanian, Ganesh, Müller-Plathe, Florian, Kolmar, Harald, Meyer-Almes, Franz-Josef

Journal:

Biological Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 2.19 MB

english, 2014

19

Synthesis of azobenzenealkylmaleimide probes to photocontrol the enzyme activity of a bacterial histone deacetylase-like amidohydrolase

Horstmann, Benjamin, Korbus, Michael, Friedmann, Tatjana, Wolff, Christiane, Thiele, Christina Marie, Meyer-Almes, Franz-Josef

Journal:

Bioorganic Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 997 KB

english, 2014

20

The cis -state of an azobenzene photoswitch is stabilized through specific interactions with a protein surface

Korbus, Michael, Backé, Sarah, Meyer-Almes, Franz-Josef

Journal:

Journal of Molecular Recognition

Année:

2015

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2015

21

Kinetic binding assays for the analysis of protein–ligand interactions

Meyer-Almes, Franz-Josef

Journal:

Drug Discovery Today: Technologies

Année:

2015

Langue:

english

Fichier:

PDF, 752 KB

english, 2015

22

Discrimination between conformational selection and induced fit protein–ligand binding using Integrated Global Fit analysis

Meyer-Almes, Franz-Josef

Journal:

European Biophysics Journal

Année:

2016

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2016

23

Substrate specificity and function of acetylpolyamine amidohydrolases fromPseudomonas aeruginosa

Krämer, Andreas, Herzer, Jan, Overhage, Joerg, Meyer-Almes, Franz-Josef

Journal:

BMC Biochemistry

Année:

2016

Langue:

english

Fichier:

PDF, 3.64 MB

english, 2016

24

Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay

Wegener, Dennis, Hildmann, Christian, Riester, Daniel, Schober, Andreas, Meyer-Almes, Franz-Josef, Deubzer, Hedwig E., Oehme, Ina, Witt, Olaf, Lang, Siegmund, Jaensch, Martina, Makarov, Vadim, Lange,

Journal:

Biochemical Journal

Année:

2008

Langue:

english

Fichier:

PDF, 315 KB

english, 2008

25

Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors

Weston, Claire E., Krämer, Andreas, Colin, Felix, Yildiz, Özkan, Baud, Matthias G. J., Meyer-Almes, Franz-Josef, Fuchter, Matthew J.

Journal:

ACS Infectious Diseases

Année:

2016

Langue:

english

Fichier:

PDF, 2.39 MB

english, 2016

26

Potent and Selective Non-hydroxamate Histone Deacetylase 8 Inhibitors

Kleinschek, Alexander, Meyners, Christian, Digiorgio, Eros, Brancolini, Claudio, Meyer-Almes, Franz-Josef

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 964 KB

english, 2016

27

Crystal structure of a histone deacetylase homolog from Pseudomonas aeruginosa

Kraemer, Andreas, Wagner, Thomas, Yildiz, Özkan, Meyer-Almes, Franz-Josef

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 2.12 MB

english, 2016

28

A Fluorescence-Lifetime-Based Binding Assay for Class IIa Histone Deacetylases

Meyners, Christian, Mertens, Monique, Wessig, Pablo, Meyer-Almes, Franz-Josef

Journal:

Chemistry - A European Journal

Année:

2017

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2017

29

Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa

Meyners, Christian, Wolff, Benjamin, Kleinschek, Alexander, Krämer, Andreas, Meyer-Almes, Franz-Josef

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 1001 KB

english, 2017

30

The thermodynamic signature of ligand binding to histone deacetylase-like amidohydrolases is most sensitive to the flexibility in the L2-loop lining the active site pocket

Meyners, Christian, Krämer, Andreas, Yildiz, Özkan, Meyer-Almes, Franz-Josef

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

2017

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2017

31

Impact of binding mechanism on selective inhibition of histone deacetylase isoforms

Meyners, Christian, Meyer-Almes, Franz-Josef

Journal:

Chemical Biology & Drug Design

Année:

2017

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2017

32

Fluorescence lifetime based bioassays

Meyer-Almes, Franz-Josef

Journal:

Methods and Applications in Fluorescence

Année:

2017

Langue:

english

Fichier:

PDF, 2.85 MB

english, 2017

33

The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel

Henkel, Michael, Mitzner, David, Henklein, Peter, Meyer-Almes, Franz-Josef, Moroni, Anna, DiFrancesco, Mattia L., Henkes, Leonhard M., Kreim, Michael, Kast, Stefan M., Schubert, Ulrich, Thiel, Gerhard

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1022 KB

english, 2010

34

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

Baud, Matthias G J, Leiser, Thomas, Petrucci, Vanessa, Gunaratnam, Mekala, Neidle, Stephen, Meyer-Almes, Franz-Josef, Fuchter, Matthew J

Journal:

Beilstein Journal of Organic Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 660 KB

english, 2013

35

The enzyme activity of histone deacetylase 8 is modulated by a redox-switch

Jänsch, Niklas, Meyners, Christian, Muth, Marius, Kopranovic, Aleksandra, Witt, Olaf, Oehme, Ina, Meyer-Almes, Franz-Josef

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 979 KB

english, 2019

36

Determination of the binding mechanism of histone deacetylase inhibitors

Meyer-Almes, Franz-Josef

Journal:

Chemical Biology & Drug Design

Année:

2018

Langue:

english

Fichier:

PDF, 2.64 MB

english, 2018

37

Kinetically selective and potent inhibitors of HDAC8

Schweipert, Markus, Jänsch, Niklas, Sugiarto, Wisely Oki, Meyer-Almes, Franz-Josef

Journal:

Biological Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2018

38

Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

Muth, Marius, Jänsch, Niklas, Kopranovic, Aleksandra, Krämer, Andreas, Wössner, Nathalie, Jung, Manfred, Kirschhöfer, Frank, Brenner-Weiß, Gerald, Meyer-Almes, Franz-Josef

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

2019

Langue:

english

Fichier:

PDF, 7.71 MB

english, 2019

39

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

Tan, Wei, Jänsch, Niklas, Öhlmann, Tina, Meyer-Almes, Franz-Josef, Jiang, Xuefeng

Journal:

Organic Letters

Année:

2019

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2019

40

Using design of experiment to optimize enzyme activity assays

Jänsch, Niklas, Colin, Felix, Schröder, Michael, Meyer-Almes, Franz-Josef

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2019

41

Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation

Upadhyay, Neha, Tilekar, Kalpana, JÃ¤nsch, Niklas, Schweipert, Markus, Hess, Jessica D., Henze Macias, Luca, Mrowka, Piotr, Aguilera, Renato J., Choe, Jun-yong, Meyer-Almes, Franz-Josef, Ramaa, C.S.

Journal:

Bioorganic Chemistry

Année:

2020

Fichier:

PDF, 2.86 MB

2020

42

Switching the Switch: Ligand induced Disulfide Formation in HDAC8

JÃ¤nsch, Niklas, Sugiarto, Wisely Oki, Muth, Marius, Kopranovic, Aleksandra, Desczyk, Charlotte, Ballweg, Matthias, KirschhÃ¶fer, Frank, Brenner-Weiss, Gerald, Meyer-Almes, Franz-Josef

Journal:

Chemistry (Weinheim an der Bergstrasse, Germany)

Année:

2020

Fichier:

PDF, 1.76 MB

2020

43

Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential

Tilekar, Kalpana, Upadhyay, Neha, Hess, Jessica D., Macias, Lucasantiago Henze, Mrowka, Piotr, Aguilera, Renato J., Meyer-Almes, Franz-Josef, Iancu, Cristina V., Choe, Jun-yong, Ramaa, C.S.

Journal:

European Journal of Medicinal Chemistry

Année:

2020

Fichier:

PDF, 2.71 MB

2020

44

Synthesis and biological evaluation of pyrazoline and pyrrolidineâ2,5âdione hybrids as potential antitumor agents.

Tilekar, Kalpana, Upadhyay, Neha, Meyer-Almes, Franz-Josef, Loiodice, Fulvio, Yu, Anisimova Natalia, Tatiana, Spirina, Sokolova, Darina V, Smirnova, Galina B, Choe, Jun-yong, Pokrovsky, Vadim S, Lavec

Journal:

Année:

2020

Fichier:

PDF, 1.44 MB

2020

45

Repurposing approved Drugs as potential Inhibitors of 3CL-protease of SARS-CoV-2: Virtual screening and Structure Based Drug Design

Meyer-Almes, Franz-Josef

Journal:

Computational Biology and Chemistry

Année:

2020

Fichier:

PDF, 3.23 MB

2020

46

Permuted 2,4-thiazolidinedione (TZD) analogs as GLUT inhibitors and their in-vitro evaluation in leukemic cells

Tilekar, Kalpana, Upadhyay, Neha, Schweipert, Markus, Hess, Jessica D., Macias, Lucasantiago Henze, Mrowka, Piotr, Meyer-Almes, Franz-Josef, Aguilera, Renato J., Iancu, Cristina V., Choe, Jun-yong, Ra

Journal:

European Journal of Pharmaceutical Sciences

Année:

2020

Fichier:

PDF, 1.11 MB

2020

47

Pharmacophore Hybridization Approach To Discover Novel Pyrazoline-Based Hydantoin Analogs With Anti-tumor Efficacy

Upadhyay, Neha, Tilekar, Kalpana, Loiodice, Fulvio, Yu. Anisimova, Natalia, Spirina, Tatiana S., Sokolova, Darina V., Smirnova, Galina B., Choe, Jun-yong, Meyer-Almes, Franz-Josef, Pokrovsky, Vadim S.

Journal:

Bioorganic Chemistry

Année:

2020

Fichier:

PDF, 3.31 MB

2020